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The true therapeutic power of l-glutamine supplementation lies in its profound, scientifically documented ability to restore and maintain the structural integrity of the intestinal epithelium

Although targeting macropinocytosis could be a key strategy for overcoming resistance to glutamine uptake blockade, further studies are necessary to examine whether macropinocytosis can overcome tumor cell resistance to glutamine antimetabolites or GLS inhibitors that target enzymes involved directly in glutamine metabolism

Therefore, we further explored the relationship between the PI3K/AKT/mTOR signaling pathway and ferroptosis

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