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ART suppresses viral replication to undetectable levels, restoring near-normal life expectancy for people living with HIV (PLWH) ( At the cellular heart of this problem lies immunometabolism, the intricate interplay between metabolic pathways and immune cell function

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[39] The resulting reduction in per-cell copy number of mtDNA plays a role in the mitochondrial bottleneck, exploiting cell-to-cell variability to ameliorate the inheritance of damaging mutations

C., Garrett, T