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Spatiotemporal regulation of the KEAP1-NRF2 system Under physiological conditions, KEAP1 is the main regulator of the NRF2 protein level (NRF2 has a half-life of about 20 min) [120, 145]

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The key anti-inflammatory effects included: Modulation of macrophage activation states Decreased reactive nitrogen species production Reduced efferocytotic activity in treated cells Lower expression of pro-inflammatory mediators Research on corneal injuries found TB-500 suppressed multiple inflammatory mediators while maintaining bacterial clearance when combined with antibiotics

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