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This pathological process is further amplified through a vicious cycle wherein excess ammonia induces inducible NOS (iNOS)-mediated GS nitration (Cudre-Cung et al

Hcy Hcy, a sulfur-containing amino acid derived from methionine metabolism, has a normal fasting plasma concentration of 200 mol/L), its thiol-mediated reduction of receptor disulfide bonds preferentially enhances GluN2B-containing receptor activity, leading to exacerbated calcium influx and progressive excitotoxic neuronal damage (Sibarov et al