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Three trials of cognitive-behavioral therapy and two trials of mindfulness-based therapy demonstrated their superiority over wait-list control status

40(12): 130510 Rebouche CJ, Engel AG

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3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)