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Increased iron deposition on brain quantitative susceptibility mapping correlates with decreased cognitive function in alzheimers disease

In macrophages, DMF will notably activates NRF2 to protect the cells from oxidative stress and promote an anti-inflammatory phenotype (212)

Aside from SQ109, several inhibitors of MmpL3, including AU1235, ICA38, Rimonabant, NITD-349, and SPIRO, have shown a strong bactericidal ability against Mtb , and have been proven to target MmpL3 [117, 125, 128, 135]