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In adipose tissue, alterations in PER2 impair the rhythmic secretion of leptin and adiponectin, while dysfunction of REV-ERB compromises the repression of lipogenic and inflammatory genes, thereby intensifying visceral fat accumulation and promoting chronic low-grade inflammation (Szewczyk-Golec et al., 2015

During periods of nutrient scarcity, triglycerides are catalyzed into fatty acids through a lipolytic cascade involving hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), and monoacylglycerol lipase (MGL)

and Aaseth, J

PGE2 is produced in the peripheral, introduced into the NTS through vagal afferents and is further transmitted to POA through the ventral noradrenergic bundle, in which norepinephrine (NE) is released (Roth and Blatteis, 2014)

NB has shown remarkable benefit in patients with binge-eating disorder (BED) and concomitant alcohol abuse, but this result needs further evaluation (62)