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Abstract Exercise-induced oxidative stress is linked with the expression level of endogenous antioxidants, but these antioxidants cannot overcome all oxidative stress-related damages in the cells, particularly when cells are under physiological stress

While no current preclinical model can capture the full complexity and heterogeneity of BM, the selection of a system which is faithful to the most relevant disease aspects may increase predictive value

These crystals most commonly form around the joints (such as the big toe) because this is where the blood vessels are the smallest

Funding This work was supported by an Anhui University Natural Science Fund Project under Grant (NO

Limitations: FDA rejected the Barth syndrome NDA in 2021 on efficacy grounds