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Acknowledgements The authors thank N

Phase 2 trial data published in the New England Journal of Medicine (2023) demonstrated average reductions in body weight exceeding 20% over 48 weeks in some participants

A recent study showed that pharmaceutical inhibition of MEK1/2 promotes fatty acid oxidation and confers a stem cell-like memory phenotype to CD8 + T cells [65]

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Under normal physiological conditions, they are largely self-sustaining, maintaining their population through local proliferation within the CNS, minimizing reliance on circulating monocytes [19, 20]