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Patients who have undergone gastrectomy or pancreatectomy may have impaired absorption of all fat-soluble vitamins, including vitamin A ( Liver diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD), are linked to altered vitamin A homeostasis, but it remains unclear whether a vitamin A deficit contributes to the pathogenic mechanisms that can progress from MASLD to HCC ( Retinoids have also been tested in the past as therapeutic agents for many cancer types, due to their ability to promote differentiation and potentially induce cancer cell death