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Instead, it has been hypothesized that Cys35 reacts with formaldehyde directly to form an S -hydroxymethyl adduct and, in the presence of a neighboring primary amine, a thiazolidine-like adduct (see Figure 1B

doi: 10.1128/mSystems.00901-19 59

New inhibitors that target this protease successfully block viral replication, offering a dual therapeutic strategy: they inhibit the viral enzyme and disrupt the host lipid environment essential for the virus (58)

*Correspondence: Santu Ghosh, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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