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Hepatology 27 , 311316 (1998)

Clinical evidence comes in tiers: mechanistic studies (does the molecule do what it should at the cellular level?), animal studies (does it produce the expected effect in a living organism?), and human trials (does it actually work on the people who will use it?)

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What to track in a symptom diary Timing, duration, activity when it starts, affected fingers, neck/shoulder positions, associated symptoms (chest pain, shortness of breath), and response to rest or meds

This suggests that immune dysregulation, in the form of a shift toward autoimmune responses, may contribute to on-going synovitis following antibiotic treatment in the joint (146)