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Encourages healthy gene expression to support stem cell activity

When a frameshift mutation replaces the IDR acidic tail of HMGB1 with an arginine-rich basic tail, HMGB1 with a mutant tail undergoes LLPS to form droplets at a lower concentration, attenuates the dynamic and liquid fluidity of HMGB1 droplets, and facilitates HMGB1 partitioning into nuclear condensates, culminating in mispartitioning into the nucleolus

This effect was supported by a colony formation assay, where treatment with CBD, 19 , and 21 at concentrations near their IC 50 (i.e., 22, 7, and 5 M

Run at baseline and post-protocol

Det ker ogs kollagen- og VEGF-produksjonen (sttter follikkelmiljet) og undertrykker TGF-1 (blokkerer et viktig hrtapssignal)