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There are older human and clinical-observational data involving pineal peptides that suggest possible improvements in mortality, cardiovascular aging, circadian function, and general geroprotection, but those findings are not the same as definitive proof that Epitalon lengthens human life through telomere extension

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Self-reported community protocols commonly describe once-daily dosing with on/off cycling, motivated partly by the absence of any long-term human safety data and partly by a community perception of diminishing returns or tolerance over continued use

A decrease in SHBG levels leads to an increased level of free testosterone in the blood and promotion of androgenic activity

J Pharmacol Exp Ther 1994