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This medicine should not be used if you have a hereditary disease of optic nerve malfunction manifested by a sudden drop in vision, called Leber's hereditary optic neuropathy, as there is an increased risk of potentially rapid and severe optic neuropathy (destruction of optic nerve fibers)

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from p16 + versus p16 CD29 + cells isolated from an FBR-driven skeletal muscle fibrosis model in adult p16-CreER T2 ;Ai14 reporter mice 38

- chez les animaux sains : la moiti de la dose