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A third site, Site 3, at the bottom of the figure also sampled frequent contact with linoleic acid, but was not tested as a candidate for mutation given the sites proximity to the binding interface with the -subunit, reduced contact times compared to Sites 1 and 2, and the diffuse nature of the interaction surface

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Iron Dysregulation in Alzheimer's Disease: Multimodal Brain Permeable Iron Chelating Drugs, Possessing NeuroprotectiveNeurorescue and Amyloid Precursor ProteinProcessing Regulatory Activities as Therapeutic Agents. Progress in Neurobiology 82: 348360

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