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Across over 12,000 measured metabolic features, we observed a large discrepancy (73.54%) in the serum metabolome between BD patients and HCs, spotting differentially abundant microbial-derived neuroactive metabolites including multiple B-vitamins, kynurenic acid, gamma-aminobutyric acid and short-chain fatty acids

Shen H, Wang W

However, Mac-CF BMDM had a significantly higher intracellular bacterial burden 22 hours post-PsA exposure than the Ctrl counterparts ( Supplementary Figure 2H ), indicating a bacterial killing defect in the CF macrophages in vitro

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