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They concluded from their data that nicotine exposure via oral route significantly increased locomotor activity in both males and female mice and they observed peak activity during the lights-off period of the circadian cycle, i.e., the active phase in mice comparable to active phase of ADHD in humans (during the day)

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A better understanding of these mechanisms could pave the way for more efficient interventions targeting nicotine use in BD, which although speculative, may also be beneficial for the course of the BD itself

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