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Acknowledgements The authors are grateful to the Panjab University, Chandigarh for research facilities, Ensembl Plants, URGI and NCBI for data availability

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Since iron is important to ferroptosis, the specific iron mechanism has attracted a new wave of attention

The synthesis of butyrate from carbohydrates occurs through glycolysis, involving the fusion of two Acetyl-CoA molecules to form acetoacetyl-CoA, which is then gradually reduced to yield butyryl-CoA

There is a possible link between potential oxidant effects of nicotine demonstrated in this study and its modulation of ALP mediated actions 47 , collagen and ECM formation in fibroblasts 50 , which could contribute to the effects of nicotine on wound healing, applicable to the cells used in our investigation