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Improved Mood & Sleep : B12 plays a role in serotonin production, which can positively impact mood and sleep quality

Its particularly beneficial for individuals experiencing fatigue or B12 deficiency, common in strict vegetarians, older adults, or those with certain medical conditions

A 2.5 mg track has short direct data and real-world support for stable maintainers, but continuing tirzepatide has much stronger evidence than stopping. At week 112, stepping down to 5 mg preserved 16.6% weight loss versus 21.9% on the top dose and 9.9% on placebo

Some users report rapid responses within days, but this pattern reflects the minority of cases