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Intramuscular administration of the iron chelator DFO has been shown to slow cognitive decline in AD patients (282), while high concentrations of MDA and 4-HNEkey lipid peroxidation productsand reduced expression of GPX4 have been detected across multiple brain regions in AD (285)

Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL

Oxid Med Cell Longev 2018:6721530 Annunziata G, Sureda A, Orhan IE, Battino M, Arnone A, Jimnez-Garca M, Capo X, Cabot J, Sanadgol N, Giampieri F (2021) The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota