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To date, no significant drug-drug interactions have been observed across multiple study populations including bipolar mania and treatment-resistant depression

After 18 days of dosing, about 97% of the total administered radiolabel was excreted in the urine and faeces, but none were detected in muscle and the concentrations were low in milk, liver, and kidney

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This alteration of the endothelium-mediated vasorelaxation is also observed in healthy subjects affected with moderate hyperhomocysteinemia (Tawakol et al, 1997

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