Surrounding the castle, Osaka Castle Park comes alive with color in spring and autumn, when locals gather beneath the blossoms or red maple leaves a peaceful contrast to what was once a mighty samurai fortress

Blockages in blood vessels can sometimes result from substances other than blood clots, such as: Fat from the marrow of a broken long bone Collagen or other tissue Part of a tumor Air bubbles Anyone can develop blood clots that lead to acute pulmonary embolism, but certain factors can increase the risk, such as: Family medical history of blood clots or pulmonary embolism Heart disease, especially heart failure Inherited disorders that make the blood more likely to clot Certain cancers, especially pancreatic, ovarian, and lung cancer, or cancers that have spread (metastatic cancer) Surgery, especially bone, brain, or joint surgery Long-term immobility such as bed rest or inactivity during long plane or car trips Smoking Excess weight or obesity Pregnancy Birth control pills or estrogen therapy Symptoms of Acute Pulmonary Embolism Symptoms of an acute pulmonary embolism vary depending on the size of the blood clots, the amount of the lung tissue affected, and whether the patient also has heart or lung disease

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Page last updated: February 4, 2026
When someone smokes or vapes cigarettes or uses other nicotine products, these products deliver high concentrations of nicotine into the bloodstream quickly