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Intermittent and short-term reoxygenation help prevent the remodeling of pulmonary artery function and structure, as well as the proliferation, migration, and phenotypic transformation of pulmonary artery smooth muscle cells in hypoxic conditions, thus effectively reducing hypoxia-induced pulmonary hypertension [91]

Current preclinical models primarily utilize pharmacological agents or other interventions to demonstrate the principle that repairing cochlear synaptopathy can reverse behavioral evidence of tinnitus (Lu et al., 2021

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A recent study showing that an APAP overdose triggers kidney injury through apoptosis and not necrosis as in the liver [162], should be a warning against extrapolating mechanisms of cell death studied in the liver to other organs