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Multifunctional NP-based drug delivery systems (DDSs) are emerging as a robust approach to improve the combined therapy as they can load the active agents into one carrier, improve drug solubility, protect the drug from decomposition, alter the biodistribution, elevate tissue penetration, avoid rapid clearance, prolong half-life, and reduce off-target effects

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Many individuals prefer cycling patterns of 812 weeks active use followed by 48 weeks off to preserve effectiveness