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A distinctive pathological feature of ALS is the mislocalization and aggregation of phosphorylated TDP-43 (pTDP-43), a nuclear RNA-binding protein encoded by TARDBP

Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, Laska E, Ehrlich ME, Walker LC, Mathews PM, Gandy S

Animal Model:Male C57BL/6 mice (8-week-old) [4] Dosage:50 mg/kg Administration:Oral gavage

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Quantile-dependent expressivity and gene-lifestyle interactions involving high-density lipoprotein cholesterol