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however, its low bioavailability limits the interest of supplementation as therapeutic option for the treatment of patients with HCCAA

This review particularly emphasizes the roles of NR and GSNOR enzymes in NO homeostasis and NO-mediated plant responses to environmental challenges

Article highlights Progressive familial intrahepatic cholestasis (PFIC) are rare, known paediatric-onset disorders of BA secretion and transport whose diagnosis is based on clinical symptoms to be confirmed with genetic tests that often reveal homozygosity or compound heterozygosity