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Description

Mutagenicity represents an established surrogate parameter for prediction of the carcinogenic potential, and bacteria-based mutagenicity testing has demonstrated a reasonably good correlation with carcinogenicity, especially for NAs (Bercu et al

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Such individuals have limited NADPH reserves and a low ability to reduce the oxidised active drug metabolite (Fig

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Caspase-3 activities were measured with commercial kits according to the manufacturers recommendations (Abcam, AB39401)

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