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Page MJ, McKenzie JE, Bossuyt PM et al (2020) statement: an updated guideline for reporting systematic reviews

The different isoforms of ADH showed protection against alcoholic disorders in Han Chinese and Japanese (due to presence of ADH1B*2 ) and in African (due to presence of ADH1B*3)

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Research shows this specific molecular arrangement is responsible for its potent NNMT inhibitory effects