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The lysosomal acid lipase LIPL-4 plays a key role, breaking down lipids, which can be bound by lipid chaperones LBP-8 and LBP-3 (Folick et al., 2015

Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW

The ionizable lipids in the library contained abundant ester and carbonate groups, endowing them with excellent biodegradability suitable for repeated administration

10.1002/14651858.CD007280.pub3 52

Clinicians utilizing these findings have developed targeted treatment protocols, often referred to as the "Brewer Protocol," which focus on eradicating fungal colonization in the sinus cavities using biofilm disruptors and intranasal antifungals