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These pathway-level predictions were experimentally validated, as PYC significantly suppressed IL-6 and IL-1 expression in lipopolysaccharide-induced BV2 microglial cells, supporting its multi-component, multi-target mode of action ( Although in vitro studies have provided substantial evidence of anti-inflammatory activity, corresponding evaluations using in vivo models remain limited

Consequently, the findings are only preliminary and may not translate to the complex human disease

Discontinue use of retinol, active ingredients like glycolic and salicylic acids, and any topical acne creams 5-7 days before and after your treatment