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PMCID: PMC11875685

For instance, Fisher et al.[48] found up to 7-fold differences in the rates of APAP glucoronidation in a sample of 20 human livers, and Court et al.[54] found 15-fold inter-individual variability in APAP glucoronidation rates in liver microsomal fractions

Furthermore, thoracic radiotherapy frequently results in lung injury, which can be mitigated by the ferroptosis inhibitor liproxstatin-1 in murine models [150]

Perinatal exposure to low-dose methoxychlor impairs testicular development in C57BL/6 mice

However, given the dose-dependent side effects of CAF, such as CAF tolerance, restlessness, and gastrointestinal discomfort, et al., we did not attempt to use higher dosages to test whether statistically significant changes could be observed in the measured indexes