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Trajectory inference, dynamical modeling, and machine learning are now routinely used to predict aging-associated state shifts, prioritize perturbation targets, and generate testable hypotheses for rejuvenation strategies

1):3943 Chiechio S, Copani A, Zammataro M, Battaglia G, Gereau RW 4th, Nicoletti F (2010) Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain