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Description

Denileukin diftitox (Ontak), approved by the FDA in 1999 against recurrent cutaneous T-cell lymphoma, is one of the first recombinant engineered chimeric proteins that combined interleukin-2 and diphtheria toxin

By contrast, AOD-9604s human data are limited: six studies with 893 participants and little or no long-term efficacy or safety data beyond six months, so its role in lasting weight control is uncertain

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