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Notably, about 90% of uveal melanoma cases, despite being anatomically distant from the liver, metastasize to this organ, highlighting the significant role of tumor-specific characteristics and organ-specific niches in CTCs/DTCs homing [56]

Future studies should further investigate this downstream antioxidant program to better clarify the involvement of glutathione metabolism in MAPKAPK2-mediated regulation of the KEAP1/Nrf2 pathway

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N-acetylcysteine (NAC), S-adenosyl methionine (SAM), and whey protein provide precursors that the liver can use to synthesize glutathione endogenously