These studies have elucidated that the focal inflammatory demyelinating lesions in the WM that underlie the acute attacks in early MS contain CD4 + and CD8 + T cells, activated macrophages and microglia, and show evidence of active demyelination and axonal transection and injury ( With aging of MS, peripheral immune-mediated inflammation subsides and WM lesions evolve either into inactive plaques that only have sparse immune cells present or alternatively smoldering lesions that have a demyelinated core with a rim of activated microglia along the lesion edge in close proximity to lymphocytic perivascular cuffs (alternatively referred to as chronic-active or mixed active/inactive lesions)
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Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells
