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solution applications can be filtered if endotoxin removal is required

After filtering, each sample contained between 1255 and 4556 high-quality barcodes, totaling 37,001 cells, which were input to the integration pipeline

The activation of these pathways can also induce the production of growth factors, such as TGF-beta and IGF-1, which promote fibroblast proliferation and collagen synthesis, enhancing the strength and repair capacity of the ligament

The review highlights FOXO4-DRI's unique mechanism as a peptide-based senolytic with high selectivity for senescent cells, while noting challenges for clinical translation including peptide delivery and stability

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