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Fifty microliters of each plasma sample, run in duplicate, was diluted two fold for measurement

Anderson GR, Wardell SE, Cakir M, Yip C, Ahn Y-R, Ali M, et al

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Differences between animals and humans in drug metabolism, immune response and renal cell biology may cause strategies that are effective in animals to be ineffective or even toxic in humans

Although the literature is split with respect to OPC number in the aged brain, their ability to differentiate is severely impaired in humans and rodents (Sim et al., 2002