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The conclusions from these essentially negative MR findings have, however, been questioned in a well-argued critique 31 , pointing out the limitations of genetic markers that explain only a small component (i.e., 7.7% at most 5 ) of serum UA variance and querying whether the core assumptions of MR, including the absence of confounds as well as a strong association with UA, are met

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Melanogenesis is a complex process that involves a series of enzymatic and chemical reactions inside the melanosomes, resulting in the production of two types of melanin: Eumelanin and pheomelanin

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These findings suggest that metabolic heterogeneity may serve as a key biomarker for predicting metastatic potential