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Both aerobic glycolysis and pyruvate metabolism play important roles in fibroblast proliferation, myofibroblast differentiation, and fibrotic tissue alterations [61, 62]

Common challenges include: insufficient statistical power due to small sample sizes

The effects of collagen loss include fine lines and wrinkles , a loss of skin elasticity and firmness, greater drooping (jawline, cheeks), slower wound healing, and more visible pores and textural defects

Positive recombinants were selected on SC-Leu plates and further confirmed by sequencing analysis

Saravia R, Flores , Plaza-Zabala A, Busquets-Garcia A, Pastor A, de la Torre R, et al