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This molecular complex plays a central role in regulating inflammatory responses in both of these conditions

It has been shown that pathogenic bacteria or viruses in inflamed tissues promote ferroptosis in cells while activating immune cells and triggering inflammatory responses through the action of lipopolysaccharides, peptidoglycans, bacterial or viral DNA, and host cell toll-like receptors carried or released by themselves (60)

They are running an uncontrolled experiment on their own tissue

Winslow, A

Furthermore, although rare, severe toxicities like lactic acidosis are often preceded by a decline in mtDNA copy number together withrising serum lactate, suggesting that serial monitoring in high-risk individuals could allow earlier detection, although current evidence remains limited ( The utility of mtDNA extends to assessing immunological failure and exhaustion