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Additionally, studies have pointed out that ornithine decarboxylase (ODC) is a potential target for esophageal squamous cell carcinoma treatment, with its inhibitor, difluoromethylornithine (DFMO), undergoing clinical trials for related cancers (He et al., 2017), and has been used in clinical trials for the treatment of pediatric neuroblastoma (Lozier et al., 2015)

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Clinical biochemistry , 47 (4-5), 315318

Non-coeliac gluten sensitivity (NCGS) is particularly instructive here: one study found that 9 out of 10 patients with NCGS had reduced serum DAO levels, suggesting substantial overlap between gluten sensitivity, intestinal permeability, and histamine intolerance