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Map1lc3a (autophagy-related ubiquitin-like modifier LC3 A) is involved in the formation of autophagosomes, and among Map1lc3a-related pathways are selective autophagy and mitophagy, alterations in both are known as important contributors to myopathy pathogenesis 37

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It is synthesized in the liver from three amino acids - glutamic acid, glycine and cysteine - and is used by every single cell in the body

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However, this approach is often time-consuming, technically complex, and its efficiency is limited by cell-specific transfection rates