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One exceptional example is that the application of pharmacological intervention with the SLC1A5 inhibitor V9302 demonstrated remarkable selectivity in blocking glutamine uptake specifically in TNBC cells, while leaving CD8 + T cells unaffected [134]

The glutaminase encoded by GLS2 can be directly bound and transcriptionally induced by p53, reducing cellular sensitivity to ROS-associated apoptosis, possibly through glutathione-dependent antioxidant defense (Suzuki et al., 2010

This distinction is crucial for appropriate clinical investigation and management

Our main organ of detoxification of acidic waste products is the lymphatic system and the liver

Then, cancer cell invasion into LVs is facilitated by the high interstitial fluid pressure inside the tumor (138) ( Figure 4A )