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doi: 10.1016/j.fct.2014.12.003 17 Daz de Len-MartnezL.Daz-BarrigaF.BarbierO.OrtzD

However, more research is needed to support this

When prolactin is evaluated by two-site immunometric assays, large amounts of prolactin saturate both the capture and the signal antibodies, impairing their binding, causing serum prolactin to be underestimated (the so-called high-dose hook effect)

These observations suggest that irisin may potentially modulate lactate metabolism and mitochondrial function in dopaminergic neurons via the SIRT1 pathway