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When retatrutide binds to GLP-1 receptors, it stimulates insulin release from the pancreas, reduces glucagon secretion, delays gastric emptying, and suppresses appetite through direct signaling to the brain

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Am J Pathol 186, 27832797

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Yui, K., Imataka, G., & Shiohama, T

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Kaur L, Zhawar VK

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10.1016/j.cub.2005.02.037 31

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