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TZ and CY wrote and revised the manuscript

[DOI] [PubMed] [Google Scholar] 141.Sakamoto T, Hara M, Higaki Y et al

Poddar K, Kolge S, Bezman L, et al

The FDA has consistently made the widest use of the FRPs compared with other regulators and has achieved the shortest time to approval amongst leading NRAs

Figure 1 ALS is a fatal neurodegenerative disease characterized by progressive degeneration of both the upper and lower motor neurons, which display cytoplasmic inclusions (Rowland and Shneider, 2001