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P-gp substrates and inhibitors are structurally diverse, and some peptides (cyclosporine being the most notable example) are potent P-gp inhibitors [11]

5 What Causes Sjgrens Syndrome Mitochondria Dysfunction Mitochondria dysfunction is thought to be a possible cause of Sjgrens Syndrome

The lessons learned from astrocyte-targeted strategies provide a natural transition to examining microglia, whose dual role as immune defenders and potential drivers of pathology makes them equally compelling therapeutic targets (Figure 5)

It can also be associated with gliosis in the affected area or alter the integrity of the blood-brain barrier resulting in inflammatory events and altered tissue vascularization (Stephenson et al., 2014)

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