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References to published literature are provided for educational purposes only

GHK-Cu binds to extracellular matrix proteins (collagen, fibronectin, heparan sulfate proteoglycans) and copper-dependent enzymes like lysyl oxidase

Englund A, Lange AH, Hagemann CA, et al

The micro-channels created by the needles also temporarily increase permeability, improving topical GHK-Cu uptake if applied in the post-procedure window