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First, we created a model organism geneset by collecting results from five animal models of nicotine exposure (RNA expression changes in brain) and then tested the relevance of these genes and flanking genetic variation using genetic data from human cigarettes per day (UK BioBank N = 123,844

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In response, tobacco companies advertising campaigns suggested that smoking was a way to remain thin [For example, To keep a slender figure, no one can deny, reach for a Lucky instead of a sweet' The American Tobacco Company, 1929] and created brands to imply that one could have a svelte figure from cigarettes [Philip Morris Virginia Slims (1968) and The American Tobacco Companys Silva Thins (1967)]

There has been debate in the public health community regarding the impact of ENDS on public health